Bostonians blame Trump for their biotech slump

Nearly everyone in Boston expressed hatred for President Trump v1.0, despite the fact that 2017-2020 coincided with great economic times for the city and state (the final year of Trump’s first term wasn’t so great due to the self-inflicted wounds of lockdown and school closure). Now that the Massachusetts biotech industry is sagging, they’re blaming President Trump 2.0,

First, are the good times over? The Wall Street Journal says that they are:

Massachusetts experienced a slight decline in its roughly 65,000 biotech research-and-development jobs in 2024 after years of mostly strong increases, including during the Covid-19 pandemic, according to federal data. The numbers indicate that job losses continued through at least June, while hiring remains sluggish.

By the end of September, nearly 28% of greater Boston’s laboratory space sat empty, according to the latest estimates from real-estate firm CBRE.

Folks in Massachusetts who decry inequality are especially upset that some federal money is being spent in places that aren’t as rich as Massachusetts:

“Every stage of the life cycle has been impacted by policy or regulatory uncertainty this year,” said Kendalle Burlin O’Connell, chief executive of MassBio, an industry trade group. The impact has hit startups especially hard, she said.

A continued downturn poses risks for a region where workers will put up with sky-high real-estate costs if they can land high-paying jobs. Massachusetts faces competition from other states and China, which are eager to peel away talent and investment.

“There are states and countries chasing us every single day,” Gov. Maura Healey said in an interview.

On the federal front, the Trump administration has terminated tens of millions of dollars in active grants in Massachusetts this year, according to Grant Witness, an independent group of researchers tracking grant terminations and reinstatements by government science agencies.

Also, while Massachusetts gets the most National Institutes of Health funding of any state on a per capita basis, changes are afoot. The NIH announced a strategy in November to promote “broad distribution and geographic balance” by spreading around future research funding.

(Does the governor have any experience in building or attracting businesses? It is unclear. “Massachusetts’ Attorney General Maura Healey becomes 1st lesbian elected governor in U.S.” (state-sponsored PBS) doesn’t explain the governor’s background other than “she is lesbian”.)

A friend who is a senior administrator at Harvard was spewing venom at Donald Trump in April for “cutting NSF funding” and thus destroying Maskachusetts. I refrained from pointing out that Congress sets NSF funding levels, not the president, no matter how much of a hater he/she/ze/they might be. Instead I asked her why she expected Boston biotech to stay on the gravy train given that Boston biotech hadn’t developed any drugs that are significant to the average human. She responded with “CRISPR”. I refrained from pointing out that most of the work on CRISPR was done at UC Berkeley and in Europe (the Nobel winners were Jennifer Doudna (Berkeley) and Emmanuelle Charpentier (variety of European institutions, including Max Planck, which has a single American outpost… in Jupiter, Florida), but did note that there isn’t any widely available treatment based on CRISPR. She said that there would be, but for Donald Trump’s interference.

I did ask why she expected Boston biotech to continue standing under the money shower if Boston hadn’t developed any of the recent blockbuster drugs. I said maybe investors, including NSF, would keep pouring money in if Boston-based companies had developed Ozempic. She corrected me: Ozempic was developed in Boston (ChatGPT says it was developed by Danes in Denmark working for Novo Nordisk; related drug Wegovy is also from Novo Nordisk; related drug Mounjaro was developed in Indianapolis by Eli Lilly). It occurred to me that today’s Boston Soviets have a mental attitude just like our charicature of 1970s Russian Soviets, i.e., any failures can be blamed on outsiders (the U.S. for 1970s Russians; Donald Trump for Bostonians in the 2020s) and any inventions worldwide can be attributed to heroic local Soviets.

Maybe Boston-based companies developed whatever class of drugs whose sales were comparable to GLP-1 ($75 billion/year)? The last time the pharma world had something of similar value was with the statin, discovered by Akira Endo at Sankyo in the Japan section of Boston and turned into an FDA-approved pill by scientists in the Rahway, New Jersey section of Boston at Merck. (I’ve always been a statin skeptic, incidentally; if a blood test shows high cholesterol because a human is fat and sedentary, a pill that changes the blood test result without changing the fat/sedentary problem doesn’t seem like it will lead to immortality.)

ChatGPT on inflation-adjusted NSF spending, showing modest growth during Trump v1.0, a bump during coronapanic, and a sag that began during the Biden-Harris administration (money was diverted to supporting migrants?):

The Harvard employee’s focus on NSF might be misplaced. Consistent with the WSJ’s reporting, it seems to be NIH that funds more biotech. NIH’s total research funding is about $27 billion, much larger than NSF’s entire budget. NIH will fund clinical trials and NSF won’t.

Given that Americans were so passionate about avoiding death from disease during coronapanic, while remaining indifferent to being killed in car accidents (imagine the lives safe with my 35 mph computer-enforced speed limit!), from lifestyle choices such as consuming alcohol and marijuana all day, etc., it surprises me that NIH funding hasn’t doubled, in real terms, since 2017. Maybe the explanation is that the entitlement/welfare/migrant-welcoming systems consume all of the growth in government spending.

Probably the real explanation for the Boston slump is that the boom was too good to last, as one WSJ source said:

“There was so much money that the sector got overbuilt,” said Alexis Borisy, founder of Boston-based Curie.Bio, a biotech venture firm that has raised more than $1 billion for early-stage biotechs. “If there was a good idea, there’d be 10 companies all built at the same time to go do it.”

It’s still interesting to me that Bostonians felt that it was their right to claim an ever-expanding share of federal tax dollars and of GDP, despite not having delivered any medications that improve the average American’s health or life. The Righteous of Maskachusetts are quick to criticize “white male entitlement”, but what is a more “entitled” attitude than expecting to stay on the gravy train after decades of underdelivering?

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Ozempic/GLP-1 drugs are yet another way for Boomers to steal from those of working age

Just as GLP-1 drugs hit the mainstream, the last of us Baby Boomers hits the minimum Social Security retirement age (1964+62=2026).

Working-age slaves pay taxes to fund Boomers’ Medicare. These costs will increase because GLP-1 drugs are expensive. Working-age slaves pay taxes to fund Boomers’ Social Security (our beloved Ponzi scheme). Boomers will now live 10 years longer because they’ll all be back to their design weight via GLP-1. A Boomer who lives longer will drain Social Security, thus forcing those of working age to pay higher tax rates and/or receive lower benefits themselves (maybe those of current working age will become eligible for Social Security at age 85?). A Boomer who lives longer in a state such as California will hog prime real estate due to Proposition 13 that caps property tax increases on long-held real estate (we have the same thing in Florida, but it is limited to a primary residence). Boomers who are mostly blind will inflict massive traffic jams on those of working age by going for jaunts in their self-driving cars, thus stealing time from the working age Americans who support the comfortably retired.

Here’s the latest expensive drug (Retatrutide) that the working age slaves will have to buy for us Boomers:

Google AI: “Experts estimate the monthly cost could range between $1,000 and $1,500+ once available. … Phase 3 trials are expected to conclude in Q3 2026, with potential commercial release following afterward.”

Novo Nordisk apparently learned from history:

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Genius doctors who actually do get paid 20X the fair price for procedures

Loyal readers may recall my previous posts on the subject of how health care providers in the U.S. are able to bill 10-15X the fair price to patients, accept the fair price from insurers, and chase after the uninsured for the absurd price. The latest: $1559 of lab work for $103. See also Recent health care scams.

The New York Times took a rare break from its “Bad Things about Donald Trump” coverage to write about some doctors who manage to collect at absurd multiples of the fair price, but from the insurance companies. “A $440,000 Breast Reduction: How Doctors Cashed In on a Consumer Protection Law” (NYT, April 22, 2026):

Dr. Norman Rowe, a plastic surgeon with offices in New York and Florida, advertises on his website that breast reduction surgery usually costs between $15,000 and $25,000.

But these days, his practice sometimes earns $440,000 for the procedure.

Dr. Rowe has taken full advantage of a new arbitration system, part of a major consumer protection law Congress passed in 2020 with bipartisan majorities. The No Surprises Act was designed to eliminate surprise medical bills, for patients who showed up in the emergency room and were treated by a doctor who didn’t take their insurance.

It bars those out-of-network doctors from billing patients directly. Instead, they can plead their case to a government-approved arbitrator. If they win, the patient’s insurer has to pay their desired amount.

By all accounts, the law is successfully protecting patients against bills from doctors they never chose. But it has also generated an expensive unanticipated consequence: Doctors have flooded the arbitration system with millions of claims. Most are winning, often collecting fees hundreds of times higher than what they could negotiate with insurers directly or what they could have earned from patients before the law passed.

When the law passed, government officials estimated that about 17,000 cases would go to arbitration a year. Instead, doctors brought 1.2 million such cases in the first half of last year, and won around 88 percent of them.

The arbitrators are doing well too. The fees they earn for deciding cases, which range from $425 to $1,150 per case, have added up. They earned $885 million from 2022 to 2024.

The chart shows that doctors get smarter every year:

How does it function in practice?

In arbitration, doctors and insurers each propose a price for the care, along with arguments for why it is appropriate. An arbitrator must pick one of the two numbers, and there is no opportunity to appeal the decision.

A neurosurgery practice outside of Philadelphia went to arbitration after the health plan Highmark offered its standard payment of $2,660 for a diagnostic procedure to measure blood flow to the brain. An arbitrator awarded it $333,000 instead.

(Let’s say that the “diagnostic procedure” is done with an MRI machine, which I think is the most expensive machine used in medicine. So the single procedure, which takes less than one hour, paid 100% of the cost of a refurbished machine or about one third of the cost of a new machine.)

Some practices are using the law to obtain high payments for routine medical care, including gynecologists who have won fees 600 times higher than usual rates for placing intrauterine contraceptive devices, or I.U.D.s.

Health policy experts have been surprised to see such lopsided results that favor doctors. Some argue that because the arbitrators are paid per case, they may have an incentive to render decisions that keep doctors coming back.

Just like Family Court! Divorce litigation that keeps everyone busy and highly paid is rare in jurisdictions where divorce litigation isn’t lucrative.

The first doctor profiled seems to have a lot of fun:

Dr. Rowe has practiced for decades on New York City’s Park Avenue and in New Jersey. Last winter, he opened an office in Palm Beach, a few miles from President Trump’s Mar-a-Lago resort. Just before the inauguration, he told The New York Post the office had been overrun with clients who wanted to look good when they “have face time with the leader of the free world.”

Dr. Rowe did not respond to multiple requests for comment from The Times.

On social media, he flaunts a lavish lifestyle. An Instagram post in February detailing his 60th birthday party featured a performance from the rapper 50 Cent and a custom-cake recreation of his 1950s vintage Porsche.

Sometimes the best paperwork is no paperwork:

Before the No Surprises Act, Dr. Rowe’s practice was out of network with EmblemHealth, but he accepted fees $30,000 or lower for hundreds of breast reduction surgeries, the lawsuit claims.

In 2024, the lawsuit says, he started routinely performing surgeries on EmblemHealth patients in hospitals that accepted the insurer’s in-network payments, though he still did not.

Under the No Surprises Act, doctors in such situations can provide patients with a waiver that warns of additional costs. If patients sign that form, the doctor has permission to bill them directly.

Dr. Rowe does not hand out that waiver. That allows him to take his payment disputes to arbitration.

He and his practice have filed more than 6,000 arbitration claims, according to an analysis of public filings from the Georgetown University Center on Health Insurance Reforms. He has won more than 85 percent of his cases.

What do our esteemed politicians have to say about this massive siphoning of GDP?

“My focus is on ensuring everyone can get the care they need without worrying about the cost,” said Patty Murray, Democrat of Washington, who helped craft the bill.

What’s incredible to me is that the U.S. economy survives our health care system!

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$1559 of lab work for $103

An average day in the U.S. health care system. Here’s a Quest Diagnostics bill for some blood tests:

The good news is that the patient paid only $103 for the tests ($83 via insurance; $20.67 via an efficient paper bill mailed in USPS) that are worth $1,559. The rain on this parade is that there is no world in which these tests are worth 15X what Quest gladly accepted as payment under United Healthcare’s negotiated rate. The only time that $1,559 would have kicked in is if Quest were pursuing a patient whose insurance fell through the cracks somehow.

I still can’t figure out how it is legal for Quest or any other health care provider to pursue an uninsured patient for 15X the fair price for its services (where “fair” = what 98% of customers pay).

Related:

  • San Francisco’s city-owned, Mark Zuckerberg-financed hospital ripping off patients with bills that are 6X the fair price: New York Post
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You’re never too old for Ozempic

While in Cambridge to teach an MIT Aero/Astro class, I got together with some old friends who are, in some cases, also fairly old. One was born in 1940 and, therefore, is 85 years old. He’s on Mounjaro (Ozempic, basically, I think). “I’ve lost 40 pounds and went off two blood pressure meds. My A1c is back to normal and my sleep apnea went away.”

What else isn’t he too old for? Coding with AI. He likes to shoot air rifles and, despite minimal tech background, used vibe coding to generate 20,000 lines of code to process data from a wind/weather sensor. “I uploaded a photo of the circuit board and the AI said ‘I understand what this board is doing’ and told me where to solder.” (not sure why he had to modify the hardware, but I guess he did)

He’s reasonably rich and wants to move to Florida, at least on the 183 days/year plan, but his wife refuses to leave Maskachusetts.

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#TrustTheScience, peanut allergy edition

New York Times, today:

For decades, as food allergy rates climbed, experts recommended that parents avoid exposing their infants to common allergens.

“We’re talking about the prevention of a potentially deadly, life-changing diagnosis,” said Dr. Edith Bracho-Sanchez, a pediatrician at Columbia University Irving Medical Center in New York, who was not involved with the study. “This is real world data of how a public health recommendation can change children’s health.”

The article never points out that parents who ignored pediatricians and public health recommendations (prior to 2017) and did the obvious thing (gradually introduce young humans to a wide range of foods that they might be expected to consume as older humans) did better by their kids.

Meanwhile, will we ever see a retraction of the advice that saliva-soaked face rags kept 2-year-olds safe from aerosol viruses that killed Americans at a median age of 82?

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Remember that Tylenol is the best thing for a pregnant person and his/her/zir/their baby

New York Times:

President Trump, speaking at the White House, gave direct and unproven medical advice contradicting decades of research about vaccines and the use of a common painkiller in pregnancy and infancy. … Medical experts, including the American College of Obstetricians and Gynecologists, stressed that acetaminophen is safe.

StatPearls/National Library of Medicine:

Acetaminophen toxicity is the second most common cause of liver transplantation worldwide and the most common cause of liver failure in the United States. Responsible for 56,000 emergency department visits and 2600 hospitalizations, acetaminophen poisoning causes 500 deaths annually in the United States. Notably, around 50% of these poisonings are unintentional, often resulting from patients misinterpreting dosing instructions or unknowingly consuming multiple acetaminophen-containing products.

I recently purchased some acetaminophen. The CVS brand expired nearly a year after the Tylenol-brand Tylenol. Maybe it would be worth paying more money and accepting the shorter expiration date in exchange for a U.S.-made product? The CVS bottle said “Made in India”. The Tylenol-brand bottle said “Active ingredient made in India.” When did Americans forget how to make common chemicals such as this one?

Note that if you’re worried about acetaminophen toxicity you could take sugar pills the next time that you’re in pain. According to “Lack of Efficacy of Acetaminophen in Treating Symptomatic Knee Osteoarthritis; A Randomized, Double-blind, Placebo-Controlled Comparison Trial With Diclofenac Sodium” (2015) and “Acetaminophen for Chronic Pain: A Systematic Review on Efficacy” (also 2015), a placebo will work just as well as Tylenol (“All included studies showed no or little efficacy with dubious clinical relevance”).

From the manufacturer in 2017:

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Righteous contempt as Florida follows Japan, Sweden, and Switzerland into non-coerced vaccination of children

ChatGPT:

Countries like Sweden, Switzerland, the Netherlands, the UK, and most of Scandinavia do not condition public school attendance on vaccination status. Japan – Vaccines are strongly promoted, but school entry is not denied for unvaccinated children. Denmark, Norway, Finland, Iceland – All Nordic countries besides Iceland follow voluntary vaccination policies for school entry. Switzerland – Vaccination is voluntary, and school entry does not depend on vaccine status.

“Which countries have mandatory childhood vaccination policies?” (Our World in Data):

A Democrat on Facebook:

What’s the punchline to this post? The author lives in… Japan, where childhood vaccines are optional. My response to him:

When do you expect the wave of unvaccinated death to hit Palm Beach, Coral Gables, Bal Harbour, Wellington, and Key Biscayne?

Note that Florida has a free “Vaccines for Children” program in which $200 million/year of injections are administered every year. Florida doesn’t have the highest vaccinate coverage rates for kindergartners, but nonetheless Florida has higher rates than the Orthodox Democrat states of Minnesota and Colorado (CDC).

The trailblazing 2SLGBTQQIA+ governor of Maskachusetts:

I personally doubt that the reduction in vaccine bureaucracy will have a large effect on standard childhood vaccination rates in Florida. People already had the option of opting out for religious reasons. Maybe the vaccination rates will go up if the lack of a legal requirement results in some additional creativity among the public health experts, e.g., free medical marijuana to any parent who brings his/her/zir/their child in for shots, convenient shot clinics at places where children are likely to gather. The Righteous assume that the only way to get humans to do something is to threaten them, but economists have found that very small financial incentives can create dramatic behavioral changes.

If we accept that the government has the right to coerce humans in the name of public health what I would do is force Americans to exercise and maintain a government-monitored BMI. Philip’s Shut-Yo-Pie-Hole System would use cameras and AI to make sure every American gets on a scale in the morning. If over 25 BMI then he/she/ze/they can’t get food other than broccoli at either a supermarket or a restaurant (control with a phone app and step tracker). Add one chicken nugget for every 5000 steps. There would be a chocolate ration of 20 grams (increased from the former value of 30 grams) for anyone with a BMI of under 21.

Loosely related, a friend in a discussion group in Maskachusetts let everyone know that he’d moved to Florida and a Democrat responded:

look on the bright side. At least you will live worry free in Florida: no state taxes, no climate change, no vaccines, and no one to tend to your lawns or clean your pools.

The emphasis on cheap/slave labor via low-skill immigration is fascinating to me. The American Righteous decided to fully open our borders to low-skill migrants almost exactly coinciding with the Age of AI/robots. (Of course, it is actually much easier to get labor in Florida than in Maskachusetts because chillin’ on taxpayer-funded housing, health care, food, etc. doesn’t pay as well in Florida as in Maskachusetts (see Table 4 in Cato’s Work v. Welfare Trade-off.)

See also

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Recent health care scams

Checking out my United Healthcare paperwork, here are some of the latest scams from the American health care system.

The eye doctor billed $1,500, which the uninsured (sucker) would have had to pay. United Healthcare cut them back to $179, apparently the fair price. The eye doctor’s technician messed up the prescription by not using the automatic refractometer to get a basic sanity check before asking me all of the “1 versus 2” questions. I went back and United Healthcare was billed another $112, which they decided should have been $34. (Shout-out to Costco, which remade two pairs of glasses with the corrected prescription at no charge.)

I went to see a different specialist. The bill was $900 for what United Healthcare said should have been $219 worth of services.

I went to a physical therapist for a $934 look at my neck (tip: don’t sit at a computer for decades!) that was worth only $130.

How did we get to the point where stuff like this doesn’t faze Americans? We’ve become accustomed to the idea that health care providers try to rip off the uninsured, that absurd prices fly around in the system until they’re negotiated down by a computer or a person at a health insurance company (and, of course, we have to pay for that negotiation since the health insurer has no source of revenue other than us), but how did that happen?

Related:

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Remembering Atul Butte

Our friend Atul Butte has died at age 55, a great physician and medical researcher who couldn’t be saved by our most advanced medicines and technology. He was always cheerful and curious.

Of his many online lectures, I think this one captures his spirit and enthusiasm well:

He and I were on opposite sides of the “saliva-soaked face rags for the general public will prevent SARS-CoV-2 transmission” debate, but it didn’t affect our friendship. Humans, even MD/PhDs, are social animals and it would have been tough for someone in the San Francisco Bay Area to take the “viruses are smarter than humans” position. Atul emphasized persuasion rather than coercion with respect to masks, unusual for an academic and doubly unusual for a University of California academic. (He did advocate coerced COVID vaccination, though, via employer mandates, and then COVID turned out not to be relevant to his own health and longevity.)

This is a sad loss for those of us who worked with Atul in the Boston area and, I’m sure, for the many younger researchers and docs whom he inspired. Also, on this Father’s Day, a terrible loss for his child. To channel Atul’s spirit, though, I guess we can be more optimistic about the future of medicine because of the techniques that Atul developed and taught to others. I’ll try to remember him every time I hear about a medical insight that came out of looking at a big data set.

From Atul’s PhD advisor:

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