Why is the conflict over Ukraine happening now?

Please forgive my ignorance of everything that happens beyond the borders of the U.S. (and/or beyond the borders of Palm Beach County), but I’m hoping that readers who follow matters international, especially those who live in Europe, can explain the Russia-Ukraine-NATO-US situation to me.

Why now? What has changed to create this conflict? Why wouldn’t it have happened in 2018, for example?

The New York Times assured us that Vladimir Putin controlled Donald Trump. From 2019, for example, “Donald Trump: The Russia File” (a consensus piece from the entire Editorial Board):

Standing on the White House lawn on Monday morning, his own government shut down around him, the president of the United States was asked by reporters if he was working for Russia.

He said that he was not. “Not only did I never work for Russia, I think it’s a disgrace that you even asked that question, because it’s a whole big fat hoax,” President Trump said.

Yet the reporters were right to ask, given Mr. Trump’s bizarre pattern of behavior toward a Russian regime that the Republican Party quite recently regarded as America’s chief rival. Indeed, it’s unnerving that more people — particularly in the leadership of the Republican Party — aren’t alarmed by Mr. Trump’s secretive communications with the Russian president, Vladimir Putin, and reliance on his word over the conclusions of American intelligence agencies.

Given the direct control of U.S. politics that U.S. media asserted that Russia was exercising from 2016 through 2020, if Putin wanted to do something in Ukraine without American interference, wouldn’t it have made sense to do it while a Russian puppet (Donald Trump) was in charge in D.C.?

Russia annexed Crimea during the Obama administration (Wikipedia) and took a lot of heat for that. Unless we/NATO/Europe has done something recently to antagonize Russia, wouldn’t it have made sense for Russia to do whatever it is doing now back in 2014 so that it would have had to suffer only one round of sanctions?

Finally, given that the U.S. is packed with immigrants from both Ukraine and Russia, I wonder what the consequences for this dispute will be here. Our corner of Florida in particular is home to both Ukrainians and Russians (many had been living in New York, Connecticut, and Massachusetts, but moved when lockdowns and school closures were imposed). Can expats from Ukraine and Russia get along? I remember when Crimea was annexed, a Massachusetts immigrant from Crimea was vocal in support of Putin and the annexation (her father was a Russian military officer).

This is a big story in U.S. media recently and yet I have no idea what Americans are supposed to know about the situation.

Related:

  • New York state public and welfare health spending compared to Russia’s military budget: How much is $88 billion? Mexico spends about $1050 per person on health care. That includes health care for the rich, middle class, and poor. Mexico’s population is roughly 130 million so this works out to about $136 billion. In other words, with only 20 million people, New York spends close to as much on public health and welfare health insurance as Mexico does to care for its entire population, including cosmetic surgery for the richest people in Polanco. (How are the results in the Mexican system? Mexican life expectancy is about one year less than American life expectancy.) Comparisons between coronavirus and war are common. What if we wanted to have a military force with supersonic fighter jets, nuclear-powered submarines, an aircraft carrier, nuclear weapons, ballistic missiles, nearly 1 million active-duty troops, and 2 million reservists? Somewhere around $70 billion is what Russia spends. In other words, New York state spends more for public health and welfare health care than Russia spends to fund what might be the world’s most powerful military (let’s hope that we never find out who is actually the strongest!).
Full post, including comments

Medical School 2020, Year 3, Week 27 (Family Medicine, Week 3)

Monday morning: 84-year-old “T-Bone” car accident victim for a hospital follow up. He was admitted to the hospital for seven days with multiple rib fractures and a wrist fracture. A CT of the abdomen showed, in addition to the acute injuries, a dilated common bile duct with the radiologist report stating, “cannot rule out malignancy versus cholelithiasis [gallstones]”. We explain to him the possibilities, and that to determine this we would need to order an endoscopic retrograde cholangiopancreaticography, a procedure in which a scope is placed down the esophagus into the small intestine and injects contrast into the biliary system. “Doc, I was just in the hospital for a week, it took everything out of me. I dont have the strength to get another anesthesia procedure. I’ve had a good life.” We agree with him, and decide to monitor with blood work.

I am beginning to work on the worksheet that we must complete before the end of our six-week rotation. Having asked the three nurses to grab me if anyone needs shots, I get several intramuscular injections checked off by giving flu shots and quadracel vaccinations to children. I also need to perform five EKGs (electrocardiograms). I see a fit 38-year-old nurse who works in the Cardiac Care Unit (CCU) and has experienced feeling faint three times within the last month. Her nursing colleagues hooked her up to telemetry, which showed “an arrhythmia”. I hook up our clinic’s EKG machine’s leads to her, but nothing happens. The three nurses all come in to help troubleshoot. We cannot fix it so we decide to have her return in a few days.

Wednesday morning, Farmer Fiona and I head into the depths of the hospital for an afternoon with occupational medicine (“OccuMed”), a clinic that treats hospital employees for work-related issues. The 32-year-old physician trained with the military before leaving to work in civilian practice. The five patients on his schedule were all no-shows, so we got a 2.5-hour sales pitch regarding the great lifestyle of an OccuMed doctor: “We have no call, our day is like a dermatologist’s.”

His team is responsible for safety protocols at the hospital. He explains the airborne precaution protocol. “OSHA  mandates a standardized nine-question questionnaire with any ‘Yes’ responses requiring a formal physical by occupational medicine. A few years ago we used a slightly different form, and we developed an in-house scoring system to determine need for a physical. Our system was actually more restrictive, requiring almost every employee to get a physical, plus we also do annual physicals on clinical workers. The higher-ups couldn’t understand why we needed to use the OSHA-approved form. What we were doing was actually illegal due to the paperwork discrepancy.” A big smile took over his face: “That’s the beauty of OccuMed. We understand the intersection between medicine, administration, and law. And it’s only getting more complex. We’re the only ones who can do this.”

Lanky Luke, Mischievous Mary, Geezer George, and I head to an impromptu Wednesday beers and burgers night. Geezer George describes the tension between the employee trying to get a work-related pay out and the OccuMed doctor working on behalf of the hospital trying to minimize the problem: “The doctor asked, ‘Could you please bend over and touch your toes.’ The patient responds, “I can’t, it hurts to move my back.’ ‘I know, but just try and touch your toes.’ ‘Okay,’ it’s going to hurt’ As he bends over and attempts to touch his toes, the physician comments, ‘So you can bend over.’ ‘Yes, but it hurts.’ He ended up getting disability.”

Luke recounts his week on inpatient pediatrics. He explains: “We admitted a six-month old with RSV [“respiratory syncytial virus,” a common illness at this age]. The baby presented to an outside emergency room where she was given an intraosseous catheter access [“IO”, a radical drill-through-the-bone procedure with significant risks that was unnecessary for this patient] and medevaced to our tertiary center. The baby was totally fine on arrival. Our attending admitted the patient overnight because the baby was helicoptered in and said ‘The patient has an IO so I guess we should use it.'” Samantha, the PA wife, recounted a similar experience: “We had a patient with chest pain — no troponin or EKG changes — medevaced to our hospital. My attending commented that he would never have been admitted if he’d come into the ED, but he was helicoptered in from six hours away. We let him stay the night under observation.”

Thursday: I spend 30 minutes talking with a fit 64-year-old who had bilateral total hip arthroplasties (replacements) over a decade earlier. After a tooth extraction, he was admitted for a 5-day ICU admission for sepsis in both of these artificial joints. He underwent two surgeries and a 50-day rehab stay. He is now doing a 3-week antibiotic holiday to confirm no infection before a revision. He is back home, but is not allowed any weight bearing on either leg.

The next clinic patient is a 35-year-old female, BMI 32, with a history of depression and polysubstance use disorder (alcohol, benzodiazepines, and cocaine) presenting as a new patient due to worsening shortness of breath. She explains she drinks a few beers on the weekend, but has been sober from other drugs for the past three years. She is also very upfront about being incarcerated for the past three years: “I was selling cocaine and meth.” My attending: “I always find it ironic when a drug user includes incarceration years as part of their sobriety time.” We order an echo, but strongly suspect she is drinking causing an alcohol-induced cardiomyopathy. We discontinue her seroquel, which might help her lose some weight, order an echo, and instruct her to stop drinking alcohol.

We are required to attend an Alcoholic Anonymous (“AA”) meeting as part of this rotation.  Wildflower Willow and I select a Thursday evening meeting through the AA online portal (there are more than 10 within a 20-mile radius every night). The leader asks the 35 attendees if anyone new would like to introduce themselves. Older people tend to be sober and say “I am an alcoholic” while the members who are our age are more likely to be active users and say “I am alcoholic and an addict”. Willow: “I didn’t like it, it felt like we were sent to the zoo to learn from the freaks firsthand.”

Friday morning: “Medicine” grand rounds on gastrointestinal bleeding at the hospital, then head to the clinic around 9:00 am. I burn several actinic keratosis  (“AK”, a common precancerous skin lesion) off with cryotherapy. Doctor Dunker lets me do two punch biopsies on a patient with numerous nevi (moles) on his back. I grab supplies, including local anesthesia, suture, drapes, needle driver, and forceps. The next step is to draw lidocaine and epinephrine into a syringe and inject to anesthetize the nevi sites until a “wheal” forms.

Doctor Dunker sees that I am comfortable getting the supplies, so he lets me do an excisional biopsy on a later patient whose previous punch biopsy pathology results showed a squamous cell carcinoma in situ, but with “positive margins” (i.e., the cylindrical punch biopsy did not remove the entire lesion). Steps: acquire supplies, prep the site with iodine, use a sterile marker to outline a 1cm margin around the lesion, incise with scalpel until reached subcutaneous fat, cut tissue with scissors, place into tissue container, suture wound close. Doctor Dunker: “Great job. Haven’t seen anyone hand-tie in quite awhile.” (As opposed to “instrument tying” using a forceps and needle driver.) This was my first time doing surgery on a conscious patient.

The last patient of the day: 47-year-old overweight female on birth control presenting for an annual wellness visit and mentions foot pain when walking. The ankle appears swollen and slightly inflamed. Although the patient does not report any worsening shortness of breath, our concern is she may have a deep venous thrombosis of the lower extremity (“DVT”, a clot in the leg, which can throw small chunks into circulation until they reach the lung). Alternatively, it could just be a sore muscle. Following the standard protocols, which are heavily biased toward defensive medicine, Doctor Dunker decides to send the patient to the ED. “Every doc will get burned by a PE [pulmonary embolism]. I wonder how many CTs it takes to diagnose one PE? How many CTs to save one life for a PE?”  (After a no-doubt multi-thousand dollar bill to the insurance company, and a whopping deductible cost for this rare privately insured patient, the hospital determines that there is no DVT.)

Statistics for the week… Study: 8 hours. Sleep: 9 hours/night; Fun: 1 night.

The rest of the book: http://fifthchance.com/MedicalSchool2020

Full post, including comments

Malawi and the Church of Sweden

From state-sponsored media, “Africa may have reached the pandemic’s holy grail”:

So to fill in the true picture, Jambo and his collaborators turned to another potential source of information: a repository of blood samples that had been collected from Malawians month after month by the national blood bank. And they checked how many of those samples had antibodies for the coronavirus. Their finding: By the start of Malawi’s third COVID-19 wave with the delta variant last summer, as much as 80% of the population had already been infected with some strain of the coronavirus.

Similar studies have been done in other African countries, including Kenya, Madagascar and South Africa, adds Jambo. “And practically in every place they’ve done this, the results are exactly the same” — very high prevalence of infection detected well before the arrival of the omicron variant.

(note that the NPR article is free of the hate speech term “herd immunity”)

By summer of 2021, in other words, 80 percent of Malawians had been infected by SARS-CoV-2. Is that because they were Church of Sweden “experimenters” who failed to close schools, wear masks, and lock down citizens? No. Children lost a year of education. Residents were subject to lockdowns (example). People were ordered to wear masks (VOA).

The central tenet of the Church of Sweden is that, at least for a non-island non-Chinese country, lockdowns, mask orders, school closures, and other government actions have a minimal effect on a respiratory virus.

Is it fair to say that Malawi and other African nations that flexed their public health technocratic muscles have proved Anders Tegnell and colleagues correct?

Some Malawians who escaped the lockdowns… (source)

Related:

Full post, including comments

Medical School 2020, Year 3, Week 26

Week 2 on family medicine rotation. Monday morning begins with a one-hour lecture by a 53-year-old talkative palliative care specialist (“helping patients learn how to live with serious illnesses”).

Palliative care was recognized as a speciality by the American Medical Association in 2008. “The profession has exploded since insurance realized that palliative care consultations save money. The problem is we don’t have enough fellowships to meet the demand.”  She would like her colleagues to be involved with CHF, COPD, cancer treatment, dialysis, and dementia when a patient has a life expectancy of less than 18 months. She adds, “We are far behind Canada with integration of palliative care into medical management. For example, palliative care specialists are typically at every Canadian dialysis and heart failure clinic.” Why is the U.S. lagging? “Political motivation,” she responded. “Palliative care became known as the ‘Death Squad’ created by ObamaCare.”

In the old days, every physician was considered qualified to educate patients and families about the logistics and prognostics of different care options, e.g., whether to agree to surgery or proceed with intubation in a terminal disease. Now the conversation gets punted to a credentialed separate specialty: “We also investigate the reasoning behind a family’s decision, we sometimes just listen but we can also use evidence-based methods to guide a patient to a more informed decision,” she explained. “For example, a 27-year-old polysubstance user got into a car crash. The ICU team doesn’t want to intubate because they fear it is unlikely the patient will ever be extubated. The mother wants the whole nine yards. We came in to talk to the family for goals of care and learned that the mother’s insistence was driven by a fear that the son was going to Hell. We coordinated chaplain services and eventually the mother agreed that it was time to let the son pass away.” (Hospitals have a substantial financial incentive to bring in palliative care specialists, who can bill more per hour than an internal medicine (hospitalist) physician.)

Roughly 80 percent of the time, she is discouraging patients from opting for expensive yet low-value procedures. In some cases, however, it is the palliative care doctor who pushes for a procedure: “A 38-year-old male had multiple life-threatening injuries including spinal cord compression and blunt abdominal trauma leading to a partial colectomy and colostomy after an industrial work accident. He was in constant pain. His neurosurgeon recommended against spinal cord decompression due to the high risks of surgery. We recommended he undergo it even though it would likely worsen life expectancy because the family and patient could not bear to see him in so much pain.”

Farmer Fiona and I happen to be assigned to palliative care for Monday, so after the lecture we head over with the attending to the palliative care team room. Each of us sees two patients. I sit in on a family meeting concerning a heavily sedated 69-year-old male with COPD and congestive heart failure in the ICU. The family has been debating for three weeks whether to stop the pacemaker that is keeping the patient alive. The wife is tearful, but says it is what he would want. “He wouldn’t want to live like this in the hospital.”

[Editor: It is always the spouse who wants to pull the plug, citing a never-committed-to-writing desire to be dead rather than sick, and the kids who want to keep a parent alive. Keep that in mind when setting up a health care proxy.]

After the meeting, we call the cardiology service. Some providers and device manufacturer representatives are hesitant about stopping the life-saving device. “One of the cardiologists on the service refuses to do these types of procedures,” says the attending, “but the one on tomorrow understands.” The manufacturer rep pushed back, but eventually relented after discussion with the cardiologist. We scheduled the shut down for the next day. This would allow the family from out of town to be present for the patient’s final hours. 

I join the attending for a new patient in the neurotrauma ICU. The 67-year-old male recently had a car accident and was coded for 10 minutes until a pulse came back. We don’t know anything about neurosurgery and haven’t talked to the patient’s neurosurgeons, but we have read some notes in Epic and supposedly have expertise in how to break bad news to patients. We had a (necessarily) vague conversation that might have helped the family formulate some questions for the neurosurgery team and most definitely helped the hospital collect revenue from Medicare.

Tuesday: family medicine clinic. The first patient is a 43-year-old father of two and aircraft mechanic for UPS presenting for an annual checkup. We discuss indications for statins given his 10-year cardiovascular risk above 7.5 percent. We prescribe Lipitor and counsel regarding smoking cessation. He mentions job-related back pain. Doctor Dunker performs a brief strain/counter-strain OMT technique. “What I really need is a massage from my wife.” Doctor Dunker jokes:,”Want me to write a doctor’s note?”

During annual visits, we evaluate USPSTF (United States Preventive Services Task Force, a panel of experts appointed by the Department of Health and Human Services) Grade A/B screenings and CDC vaccine recommendations. We often have a discussion about the new shingles vaccine, Shingrix. Our office does not carry the vaccine, which costs $100 at a local pharmacy and Medicare Part A or Part B do not cover this. Patients on whom taxpayers are spending $10,000 or more annually balk at the idea of paying $100 dollars to cut their risk of getting shingles from 33 percent to about 1 percent.

Doctor Dunker recounts several patients that have permanent life-altering complications from shingles, namely postherpetic neuralgia. “I had a retired nurse commit suicide because of the intense pain. It is just like trigeminal neuralgia.” (Also known as the “suicide disease”, trigeminal neuralgia is a chronic pain disorder with recurrent episodes of intense, unexpected jolts of pain on one side of the face that last for a few seconds.)

I sit in on a visit for a 68-year-old female active smoker with congestive heart failure (CHF) who does not understand her disease. She arrives with a “care coordinator,” a nurse with extra training whose job is to prevent hospital readmissions and reduce the chance that the hospital will get dinged by Medicare under the Readmissions Reduction Program (RRP). She has had two CHF exacerbations requiring readmission due to a lack of understanding of her medications and when she should take her “fluid” pill to avoid becoming volume-overloaded. I use her chest x-ray from the most recent admission to explain why she’s becoming short of breath and  say that we will likely need to increase her metoprolol dose to control atrial fibrillation and keep her heart rate below 110 beats per minute. Her INR (international normalized rate, a measure of blood clotting when on Coumadin) from today’s in-house blood draw was increased. I told her that the hospital’s latest amiodarone prescription may be responsible. I feel like I am getting the hang of outpatient medicine!

Thursday afternoon: playing around with Epic and notice an InBasket message, which I hadn’t realized we have access to. Who would send me something in this? It is a request from Doctor Dunker that I look up ectopic kidney (kidney located in the pelvis). I do research on UpToDate.com and present findings to Doctor Dunker to help him prepare for a meeting with a family and their newborn. I explain the main considerations in management of ectopic kidney are: (1) risk of hydroureter/hydronephrosis,  (2) association with other congenital anomalies, and (3) increased risk of urinary tract infections

Doctor Dunker takes responsibility for his patients, a contrast to the hospital’s poor continuity of care. For example, on Friday morning, we see a 72-year-old female who was admitted to the hospital the previous week for a GI bleed. The patient was stabilized on IV fluids and 2 prbc. The EGD showed no abnormalities, but because the patient stabilized a colonoscopy was not performed. She now has to wait several weeks for an elective colonoscopy. After several thousand dollars in hospital bills, still no answer. No ownership.

[Editor: It’s not all bad. Via the above incident, the hospital obtained “ownership” of several thousand tax dollars via Medicare!]

Statistics for the week… Study: 8 hours. Sleep: 9 hours/night; Fun: 1 night. Twelve classmates drive 30-minutes outside town to a new, dog-friendly brewery.

The rest of the book: http://fifthchance.com/MedicalSchool2020

Full post, including comments

Movie suggestion: Black Death

Leaving HBO Max in a few days… Black Death, a 2010 film that is perfect for “these times.” I don’t want to spoil the movie, but one critical element is attempts by people whose understanding of The Science is imperfect to explain a geographical variation in death rate. At the very least, you’ll be grateful for central heat, indoor plumbing, and telecommunications.

One unusual aspect of the movie is that, though it is set in the Middle Ages, it is not about the nobility. We see the lives of ordinary folks who are typically ignored in books and movies.

Related:

Full post, including comments

Medical School 2020, Year 3, Week 25 (Family Medicine)

We pick up our hero’s story in January 2019, halfway through Year 3.

Orientation begins at 7:00 am. Our clerkship director, a 58-year-old family doctor, explains that we are expected to write at least two notes per day at our assigned clinic. “Get used to the SmartPhrases [canned templates within Epic, with fields such as patient age ready to be auto-filled] your team uses. Half the note is just for billing, which makes it frustrating to find information even in my own notes, let alone others’. But we have to work with it.”

He describes the distinction between family medicine and general practice. “General practitioner developed bad connotations because it was basically a physician who did not complete a residency. You were considered a general practitioner (GP) in your third year of medical school. My dad delivered babies by himself as a fourth-year medical student. Family Medicine fought back against this confusion by becoming the first society to require a board examination.”

The orientation was followed by a lecture on geriatric polypharmacy (drug interactions and the consequences of our pharma-happy medical system). A geriatrician (family doctor with geriatrics fellowship) in her 50s: “More than 12 percent of the US population is over 65. An estimated 50 percent of these folks take more than five medications. Polypharmacy has serious consequences; 30 percent of hospital admissions are estimated to be from adverse drug effects.” Why aren’t the hazards of over-pharma better known? “There are a lot of studies looking for a primary discharge diagnosis of ‘adverse drug reaction’ as an ICD-10 code. They will miss a situation in which the adverse drug reaction caused the primary problem, e.g., a patient falls from too many anti-hypertensives and breaks her hip.” 

She describes Beers Criteria, a list of potentially inappropriate medications in the elderly that can lead to falls, fractures, gastrointestinal bleeds, delirium, and overall increased risk of death. “We’re trying to get away from the lady that takes a few Xanax every night for 40 years,” she exclaimed. She described analgesia in the elderly. “Too often we avoid giving opioids because of the stigma, but they are frankly one of the best options to manage pain in the elderly. The alternative of NSAIDs [e.g., Advil] causes serious GI bleeds and destroys the kidneys.”

She added, “When you get a few years under your belts, you’ll start to notice pharmaceutical tricks. When a commonly used drug is about to go generic, the company will conduct a clinical trial with a dose that cannot be obtained from a combination of pills already on the market. For example, Aricept [donepezil], medication used in Alzheimer’s dementia despite minimal clinical benefit]  comes in 10 mg and 20 mg. Before the patent expired, Pfizer conducted a trial at 22 mg. It didn’t work, but if it had, they would’ve sought FDA approval for the 22 mg level, and then insurance would have paid only for the FDA-approved dose, otherwise it would be an off-label [uninsured] use.  Same thing happened with Claritin.” She concluded: “Learn the rules, so that you may break them properly.” She requires us to conduct a polypharmacy review of an elderly patient during our rotation.

[Editor: See a March 11, 2001 New York Times story on Schering-Plough keeping Claritin from becoming an inexpensive generic via dosage tweaking leading to patent extensions: “The Claritin Effect; Prescription for Profit”.]

Farmer Fiona, a 26-year-old from rural America who is interested in rural family medicine, and I are paired for our weekly nursing home days. Fiona texts the attending who tells us to meet him at the assigned nursing home at 1:00 pm. I rush through lunch at the gas station burrito shop, but need not have hurried since the doctor does not arrive until 1:30 pm. He assigns us two patients each, one admission and one follow-up. After 45 minutes, we reunite with the attending and present our patients in a conference room. My 65-year-old patient has been in and out of the rehab facility twice after pancreatitis hospitalization complicated by an abscess formation requiring laparotomy (cut open abdomen). He is experiencing worsening nausea two days after discharge from the hospital. He has no peritoneal signs (inflammation of abdominal wall), or systemic signs of infection (fever, tachycardia). We prescribe Zofran and plan to re-evaluate him the next day for possible transfer to the hospital for imaging. We then round on 5 patients in skilled nursing, and 5 patients in the long-term care section of the assisted living complex.

Tuesday morning I drive 45 minutes into the countryside to a family medicine clinic that will be my primary home for six weeks. Work starts at 8:30 am, so I get more sleep than during the surgery and internal medicine rotations. The office has three physicians, one of whom works 2.5 days per week and spends the rest of the time with her children. It isn’t difficult to craft a work-life balance when a nice house near the clinic costs $250,000 and a full-time doc is earning $220,000/year. I will be working only with the two full-time physicians. We are able to perform lab draws (in-house A1C, CMP) and electrocardiograms, but no onsite x-ray.

Doctor Dunker is a 41-year-old member of a traditional Anabaptist group. He has seven home-schooled children, a beard that flows down to mid-chest, and dresses like an Amish farmer. He comes in at 8:30 am on the dot wearing a pressed white shirt with baggy black pants and a black vest. He expects the nurse (also in traditional garb, including bonnet) to have prepped his first patient and will put his black hat on the desk, don a white coat, and go into the exam room within a minute of arrival. Jane and I won’t be able to complain about working hard in medical school; Doctor Dunker had two young children to care for during his medical education.

He cares for a village, about 3400 patients spanning several generations of families, twice as many patients as the other full-time attending in the practice. About half are from his traditional community, many driving two hours from the rural area in which he formerly practiced, and some making all-day drives from other states. “They just keep having children, and I can’t say no.” He has learned to have low expectations for M3s: “Things are crazy around here, I actually requested to not have a medical student this block. I know this isn’t your fault. Today, you’ll just follow me. We’ll figure a way to make it work. I still want you to get comfortable with doing great outpatient encounters.  I just can’t get behind on my patients because I have to leave on time.”

The typical day has acute visits and medication follow-up visits scheduled in 15-minute blocks while new patients and annual visits are scheduled for 30 minutes. We are supposed to take a lunch break from 12:00 to 1:30 pm (oftentimes interrupted by 1 or 2 fill-in appointments) and are done at 5:00 pm. On two days per week, Doctor Dunker stays late and sees patients until 7:00 pm.

The first visit is a joint annual check up for an Anabaptist couple in their 70s. We start with a routine health check and filling out a Medicare annual form ($35 in extra revenue) that asks how long it takes the patient to “get up and go” (should be under 20 seconds to rise from sitting, walk 10 feet, turn around and sit back down), domestic violence screening, and dementia screening test with Mini-Mental Status Exam (MMSE, including a three-word recall and drawing a clock). The wife asks: “By the way, one more question. Our granddaughter is pregnant and needs a note to take five-minute breaks at Walmart when she gets short of breath. Could you do that?” He was silent for a second. “I cannot confirm or deny that she is a patient of mine or her situation.” The couple laughed, “Oh, Doc. We know she is pregnant, she told us, and we’re ecstatic. Her boyfriend, hopefully fiance, is a great guy and all about her. And by the way, you’re a terrible liar!” Doc Dunker: “If she is a patient, I will reach out to her.” As the old couple leaves, they comment approvingly on the Christian artwork.

We see a 12-year-old girl for eczema. Last visit, Doctor Dunker had ordered a compounded steroid cream. However, Medicaid had rejected the order, even though it is a generic medication. “This can be so frustrating. They reject what I order, but won’t offer an alternative.” He adds, “Finding a medication that Medicaid will pay for is like whack-a-mole.”

Doctor Dunker: “The next patient is quite interesting. Interview the patient when she arrives while I see the roomed patient.” A 37-year-old female former nurse, local but not Anabaptist, presents for a one-month follow-up after discharge from a stroke rehab program. After a routine dental procedure and despite being generally healthy, she contracted subacute bacterial endocarditis (heart valve infection). The infected valve threw clots into her arteries, one to her middle cerebral artery causing a stroke, and one to her left leg causing gangrenous necrosis. Her left leg was amputated above the knee. She was in rehab for a month, with follow-up physical and occupational therapy appointments.

The patient is way out of my league. I don’t know what questions to ask about the post-stroke recovery process. Fortunately, Doctor Dunker knocks on the door. The patient and her husband brighten, “Doc look at this. She attaches her prosthesis to the left lower extremity stump, and walks to the door. “Oh my God. Wait here.” He calls the nurses and front desk staff. “Everyone come here and watch.” People cheer as she walks down the hall.

When the commotion subsides, she explains her challenges going forward. “Insurance won’t pay for any more PT or OT [physical or occupational therapy]. My husband and I have worked too hard to go for the Medicaid spend-down, but we just can’t afford these $150 sessions out of pocket. I wish we had known what we know now. We had only 10 sessions for PT and OT. If we scheduled them back-to-back, they count as one, but we scheduled the first few at separate times so it counted for two seperate uses.” Doc Dunker: “Let me see what I can do.” He calls our care coordinator, who gets her another 10 PT and OT sessions from charity care.

[Editor: when a hospital reports “charity care”, it is at the fictitious list prices that are often 10X what an insurance company would pay. “How Much Uncompensated Care do Doctors Provide?” (NBER, November 2007) concluded that “uncompensated care amounts to only 0.8% of revenues” and that physicians actually were “earning more on uninsured patients than on insured patients with comparable treatments.”]

The next patient is a 69-year-old male, accompanied by his daughter, for worsening hallucinations associated with Lewy body dementia (LBD). LBD is characterized by early vivid visual hallucinations followed by progressive decline in cognitive function. He called 911 at 2:00 am because he thought his wife had stopped breathing (in fact, she passed away 10 years earlier). This is the fourth time he has called 911 for a hallucination. He describes how he sometimes sees large beetles (“size of my hand”) crawling on him at night. My attending describes this phenomenon where objects appear bigger or smaller than reality as Lilliputian, dubbed the “Alice in Wonderland” syndrome. The patient is quiet throughout the interview, clearly embarrassed about his behavior. Afterwards, we just sit in the room for a few seconds. “So sad, his body is fit but his mind is failing him. He knows right now he has a problem. This can be the most devastating period of the dementia.” (Robin Williams who committed suicide at 63 suffered from the “terror” of LBD.)

[Editor: Williams was also being pursued by two alimony plaintiffs. New York Daily News: “Paying out over $30 million

Full post, including comments

A corrected history of mRNA vaccines

According to the world’s most prestigious scientific journal, here’s how the history of mRNA vaccines begins:

In late 1987, Robert Malone performed a landmark experiment. He mixed strands of messenger RNA with droplets of fat, to create a kind of molecular stew. Human cells bathed in this genetic gumbo absorbed the mRNA, and began producing proteins from it.

Realizing that this discovery might have far-reaching potential in medicine, Malone, a graduate student at the Salk Institute for Biological Studies in La Jolla, California, later jotted down some notes, which he signed and dated. If cells could create proteins from mRNA delivered into them, he wrote on 11 January 1988, it might be possible to “treat RNA as a drug”. Another member of the Salk lab signed the notes, too, for posterity. Later that year, Malone’s experiments showed that frog embryos absorbed such mRNA. It was the first time anyone had used fatty droplets to ease mRNA’s passage into a living organism.

Those experiments were a stepping stone towards two of the most important and profitable vaccines in history: the mRNA-based COVID-19 vaccines given to hundreds of millions of people around the world. Global sales of these are expected to top US$50 billion in 2021 alone.

The above Nature article is dated September 14, 2021. In late December 2021/early January 2022, the above-referenced Robert Malone was censored by YouTube (UK Independent) and unpersoned by Twitter (Daily Mail). A mixture from the two sources:

Given the doctor’s contested views on Covid-19, including his opposition to vaccine mandates for minors, the act by YouTube has sparked several accusations of censorship amongst right-wing politicians and political commentators.

Malone even questioned the effectiveness of Pfizer’s Covid-19 vaccine in a tweet posted the day before his account was suspended on December 30

He told Rogan that government-imposed vaccine mandates are destroying the medical field ‘for financial incentives (and) political a**-covering’

Malone responded by questioning: ‘If it’s not okay for me to be a part of the conversation even though I’m pointing out scientific facts that may be inconvenient, then who is?’

(What did Malone do for work between 1987 and now? According to Wikipedia, he graduated medical school in 1991, was a postdoc at Harvard Medical School (yay!), and then worked in biotech, including on vaccine projects. “Until 2020, Malone was chief medical officer at Alchem Laboratories, a Florida pharmaceutical company,” suggests that he might live here in the Florida Free State.)

How long would we have to wait for a corrected history of mRNA vaccines from which the unpersoned Malone would be absent? January 15, 2022, “Halting Progress and Happy Accidents: How mRNA Vaccines Were Made” (New York Times), a 30-screen story on my desktop PC. The Times history starts in medias res, but if we scroll down to the point in time where Nature credits Malone, both Malone and Salk are missing:

The vaccines were possible only because of efforts in three areas. The first began more than 60 years ago with the discovery of mRNA, the genetic molecule that helps cells make proteins. A few decades later, two scientists in Pennsylvania decided to pursue what seemed like a pipe dream: using the molecule to command cells to make tiny pieces of viruses that would strengthen the immune system.

The second effort took place in the private sector, as biotechnology companies in Canada in the budding field of gene therapy — the modification or repair of genes to treat diseases — searched for a way to protect fragile genetic molecules so they could be safely delivered to human cells.

The third crucial line of inquiry began in the 1990s, when the U.S. government embarked on a multibillion-dollar quest to find a vaccine to prevent AIDS. That effort funded a group of scientists who tried to target the all-important “spikes” on H.I.V. viruses that allow them to invade cells. The work has not resulted in a successful H.I.V. vaccine. But some of these researchers, including Dr. Graham, veered from the mission and eventually unlocked secrets that allowed the spikes on coronaviruses to be mapped instead.

Perhaps the Times just didn’t have enough space in 30 screens of text to identify Malone? The journalists and editors found space to write about someone who wasn’t involved in any way:

“It was all in place — I saw it with my own eyes,” said Dr. Elizabeth Halloran, an infectious disease biostatistician at the Fred Hutchinson Cancer Research Center in Seattle who has done vaccine research for over 30 years but was not part of the effort to develop mRNA vaccines. “It was kind of miraculous.”

There was plenty of space for a photo of an innumerate 79-year-old trying to catch up on six decades of biology. The caption:

From left: Dr. Graham, President Biden, Dr. Francis Collins and Kizzmekia Corbett. The scientists were explaining the role of spike proteins to Mr. Biden during a visit to the Viral Pathogenesis Laboratory at the N.I.H. last year.

For folks in Maskachusetts who’ve had three shots and are in bed hosting an Omicron festival, the article closes with an inspiring statistic:

He was in his home office on the afternoon of Nov. 8 when he got a call about the results of the study: 95 percent efficacy, far better than anyone had dared to hope.

See also the NYT for Massachusetts hospitalization stats in a population that is 95 percent vaccinated with a 95 percent effective vaccine:

So… it was two weeks from Robert Malone being unpersoned by the Silicon Valley arbiters of what constitutes dangerous misinformation to an authoritative history in which Malone is not mentioned.

Full post, including comments

Did your free COVID tests arrive yet?

Who has received his/her/zir/their free-from-Joe-Biden COVID-19 tests? This handout seems like an ideal political strategy. People will be delighted to pay $40,000 per year in local, state, and federal taxes as long as they can get $40 (retail) in COVID tests “for free” from the benevolent pharaoh.

I’m wondering if the typical household receives these tests just as Omicron (“in retreat” due to muscular government efforts, not because of Farr’s law) has disappeared and, more importantly, if Americans will be told to discard these tests when the next wave hits because the tests won’t be sufficiently sensitive to whatever variant comes after Omicron.

Readers: What’s your prediction as to whether 90% of these tests ultimately are discarded?

Related:

Full post, including comments

What is Harvard’s argument for race-based admissions in the #StopAsianHate age?

“Supreme Court to hear Harvard admissions challenge” (Harvard Gazette):

“The Supreme Court decision to review the unanimous decisions of the lower federal courts puts at risk 40 years of legal precedent granting colleges and universities the freedom and flexibility to create diverse campus communities. Considering race as one factor among many in admissions decisions produces a more diverse student body which strengthens the learning environment for all,” he said. “The U.S. Solicitor General rightfully recognized that neither the district court’s factual findings, nor the court of appeals’ application of the Supreme Court’s precedents to those findings, warrants further review. Harvard will continue to defend vigorously its admissions practices and to reiterate the unequivocal decisions of those two federal courts: Harvard does not discriminate; our practices are consistent with Supreme Court precedent; there is no persuasive, credible evidence warranting a different outcome. The University remains committed to academic excellence, expanded opportunity, and diverse educational experiences—and to the perennial work of preparing students for fruitful careers and meaningful lives.”

The case was first tried in 2018. Federal District Court Judge Allison D. Burroughs found in favor of Harvard in her October 2019 decision on all counts, ruling that the College didn’t discriminate based on race, engage in racial balancing or the use of quotas, and that it had no suitable race-neutral alternatives that would allow it to achieve its pedagogical and diversity-related goals. Just over a year later, in November 2020, the First Circuit Court of Appeals upheld Burroughs’ decision.

Based on the above, Harvard’s argument seems to be that race-based admissions is a sacred tradition and also that diversity is critical to learning, which explains why people in China, Korea, Japan, and Taiwan are ignorant of everything except how to implement a 3 nanometer process for integrated circuits.

A lot has changed since 2018, however. Stop Asian Hate began in March 2021, months after the appeals court upheld Harvard’s scheme. The term “AAPI,” lumping together half a globe of humanity into a single victimhood category, is more or less new since the 2018 trial as well.

The effect of Harvard’s race-based system is summarized pretty well in this video, from a friend of a friend:

Now that racism against Asians is considered, by all of the best people, to be bad, what is Harvard’s argument for perpetuating its current system of race-based discrimination?

Related:

Full post, including comments

Encanto: Latinx migrants get a free house

The heart-warming story of the movie Encanto begins with Latinx migrants fleeing violence (in Colombia) and almost immediately getting a free house (created by a magic candle).

This was a hit with the elementary schoolers in our household, though it lacks a villain (there are no white non-Latinx characters and therefore nobody can be truly bad). Without a villain, a traditional element of drama is missing. The virtuous Latinx characters are essentially fighting with themselves.

It doesn’t seem as though anyone Colombian worked in a senior role on the film and therefore the work is solidly in the Hollywood tradition of cultural appropriation. Partial redemption for this sin is achieved by having the physically strongest character, able to lift an entire church due to a magic gift of strength, be someone who identifies as a young woman.

Students of zoology and geography will be pleased to see that one of the South American animals that is included in a menagerie is identified in the dialog as a “leopard” (i.e., not a jaguar). Loyal reader Toucan Sam will, no doubt, be willing to overlook this issue…

Full post, including comments