Ebola vaccine: 43 years after first outbreak

A righteous Church of Shutdowner on Facebook regarding the infidels of the frozen north:

The Swedish approach makes sense if and only if you are certain that everyone is going to get the virus in the end. If you think there is going to be a vaccine available within 18 months, it means far more deaths than necessary.

[“far more deaths than necessary” in Sweden to date translates to half as many as in Massachusetts (adjusted for population size). Their failure with continuity looks pretty good compared to our success with shutdown!]

I asked why he was confident regarding vaccine development:

We produced a vaccine for Ebola within months of the disease appearing. And right now we have every vaccine lab in the world and more looking for the COVID vaccine. The question hasn’t been time, it has been whether immunity was possible. If you have thirty world class labs each taking a shot at producing a vaccine that has a 10% chance of success, you are pretty much certain to succeed if it is possible with that approach.

I certainly hope that he is right (he’s a computer programmer, not a virologist, so he is guessing just like the rest of us!), but I decided to check out Wikipedia on Ebola and discovered that it first broke out within humans in 1976 and an approved vaccine become available 43 years later, on December 17, 2019 (i.e., we were perfectly set up to fight the last war almost to the day that the next war broke out).

(The press release might have to be walked back a bit, given recent events: “The first-ever FDA approval of a vaccine for the prevention of Ebola is a triumph of American global health leadership.”)

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The Swedes actually did have Covid-19 models

I had searched in vain to find the Swedish equivalent of the IHME model that Americans love. Surely there had to be an academic in Sweden who wanted to be interviewed by hysterical journalists about the forthcoming doomsday. Yet I couldn’t find anything in English, at least. I thought that maybe Swedes simply didn’t care how many people would get sick, when peak deaths would occur, or how many of their fellow citizens would die. They seemed to be content to let the 15 epidemiologists on the governor’s team be their only soothsayers (example).

As usual, I was dead wrong! “Can we trust Covid modelling? More evidence from Sweden” (The Spectator) shows that Sweden had its PhDs willing to make a few assumptions and then stick them into a simple model. And the ones who came up with the most dramatic forecasts of doom got some media attention. Demand for critical care was going to be “16,000 patients per day” in early May:

Another team upped this to over 20,000:

The government team thought Sweden would have 1,700 patients in the ICU right now. The actual number is around 500.

The doomsayers thought that doom was inevitable even if the Swedes converted to the Church of Shutdown:

And obviously, there is an argument that these models scared us into changing our behaviour and ramping up capacity, and so helped us to avoid a disaster. But they were also clearly based on faulty assumptions that would always result in absurd predictions. We know this, because both models actually assumed that it was already too late, and estimated that ICU capacity would be exceeded by around 10 times even if Sweden switched to strong mitigation.

The need for ICU beds in Sweden will be ‘at least 10-fold greater [than capacity] if strategies approximating the most stringent in Europe are introduced by 10 April’, wrote Gardner et al.

Those strategies were never introduced in Sweden, and yet, additional ICU capacity is 30 percent and the number of patients in intensive care has been declining for two weeks. The newly constructed field hospital in Stockholm, with room for hundreds of patients, has still not received any patients. It will probably never have to open. Here’s a zoomed-in graph of eventual ICU: numbering in the hundreds, not the predicted thousands.

(i.e., the Swedes also built a temp hospital that was never needed!)

I’m kind of curious as to why Americans have placed such faith in the prophecies offered by epidemiologists given that epidemiology is primarily a retrospective activity and there is no historical data on how virus transmission is affected by a Western-style “porous lockdown”. It is as though people in the 1980s had decided that the “complexity” theorists of the Santa Fe Institute, who also could spin a few assumptions into an interesting tale, could be relied upon as reliable oracles. People don’t have the same faith in models of the future stock market. Nobody says “I’m going to hire three PhDs, download R, and become fabulously wealthy starting next week after my team’s model tells me the future prices of stocks.”

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Elizabeth Warren wants to fight inequality with a $3 billion ferry for the nation’s richest people

Are you a lower-middle class taxpayer in Iowa or Arkansas? Elizabeth Warren wants you to buy $3 billion in ferry tickets for the nation’s richest people, i.e., folks who can afford summer houses on Martha’s Vineyard, Nantucket, and similar island retreats: “Markey, Warren, Keating Seek Federal Aid for Steamship Authority”:

With the financially strapped Steamship Authority in mind, the Massachusetts Congressional delegation is requesting $3 billion in aid to keep the country’s ferry industry afloat.

In a letter sent to Speaker of the House Nancy Pelosi and senate leaders Mitch McConnell and Chuck Schumer on May 7, Sens. Elizabeth Warren and Ed Markey, and Cong. Bill Keating pleaded for additional dollars for ferries, citing the SSA’s plummet in passenger traffic and the fiscal strains caused by the pandemic.

What else can middle-class taxpayers in the mostly plague-free “flyover” states buy for us?

(How much does $3 billion buy when it is not a U.S. state government spending the money? Indonesia has a Navy with roughly 140 vessels and 55 aircraft to patrol its 3,000 x 1,100 mile territory, which includes 17,504. islands. The total military budget of Indonesia is about $9 billion (Wikipedia), so presumably the Indonesian Navy spends close to $3 billion per year.)

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Coronanews from the Netherlands

Schools are reopening in Holland today (Reuters), but not in a Swedish business-as-usual manner. Children will be separated by walls of plastic.

Shops and businesses in the Netherlands never closed and my Dutch friend said that the general population hadn’t wanted schools to close, but “the teachers are in a union and they knew they’d get paid even if they didn’t work, so of course they immediately refused to work.”

What was his take on the continued lockdown in the U.S.? “All of the rights that Americans fought and died in multiple wars to defend, they gave up in one governor’s press conference.”

Where does Holland fit into the death-rate-so-far competition? About the same as Sweden, which continued to run schools and restaurants, and therefore less than half the death rate of my home state of Massachusetts (but more than the U.S. overall):

How about a moving average of recent deaths?

What about other businesses? From Bloomberg:

Restaurants, bars and movie theaters will be allowed reopen starting June 1, with restrictions to comply with the “1.5 meter society” which will remain in place for the foreseeable future, Prime Minister Mark Rutte told reporters at a televised briefing in The Hague on Wednesday. Prostitution, which is legal in the Netherlands, is allowed restart on Sept. 1 according to the current time line.

(Due to the border closure, workers in the Dutch sex industry cannot simply spend the summer in the U.S. and return home with a developing annuity (see “American Child Support Profits Without an American Child”))

Given that the Dutch continued to meet in shops, in public squares, and at work, how is it possible that the coronavirus hasn’t already reached nearly everyone who is susceptible? Presumably they are expecting a second wave if they reopen restaurants tomorrow, but why is June 1 any better?

Related:

  • May 2: “Wear a mask if you want to, says Dutch prime minister”: ‘Everyone can do what they like, this is a free country,’ he said. ‘But there are risks and if you use them incorrectly, they can actually help spread the virus.’
  • starting June 1: “Since public transport will probably become busier around 1 June, it will be more difficult to stay 1.5 metres apart. It will also be impossible to carry out a preliminary risk check. That is why everyone travelling on public transport will be required to wear a non-medical face mask to protect others.”
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Update on my friend who was hit with coronavirus

At the end of March, I wrote “First friend with COVID-19: mild symptoms for 5 weeks”. He recently got an antibody test:

So… he’s positive for antibodies to coronavirus, but “sensitive information, such as the sex of your baby” remains private.

His reflections on the experience:

  • “Maybe I should have taken off work when I had it.”
  • “It was like having three flus in a row.”
  • “I did some of my best work during that period.”
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If coronashutdown is to protect the old, why do young people have to pay for it?

The average age of a Covid-19-tagged death here in Massachusetts is 82. Thus, presumably to the extent that any lives are saved from Covid-19 by our educational, social, and economic shutdown, they will be roughly 82-year-old lives.

Let’s assume for sake of argument that the shutdown makes sense as a mechanism for saving lives. Flatten the Curve will save more people from Covid-19 by delaying their infection than will be killed from (a) the shutdown of regular health care, (b) poverty and unemployment, (c) starvation in poor countries, (d) the suspension of clinical trials for new drugs, (e) the suspension of clinical training for the next generation of medical doctors, etc.

Now that we’ve assumed shutdown is an actual life-saving mechanism, we come to the cost and who pays. Just this year’s federal budget deficit is on track to be $4 trillion. So that’s $4 trillion that will be borrowed before the inevitable bailout of the big-spending state governments (not allowed to issue bonds so they borrow by making public employee pension promises that they don’t fund).

The ordinary borrowing mechanism of the federal government imposes the costs onto people who are still young enough to work and pay taxes, right? And since federal government tends not to repay debt, but merely roll it over and pay more interest, the younger the person the more he/she/ze/they will have to pay, right? Is it fair to say, then, that Americans who are currently in their 20s will bear the highest burden from coronashutdown? (current children will pay too, but they won’t start paying taxes for a few years yet so their future payments have to be discounted)

Is this our revenge on them for saying “OK Boomer”?

(The young folks above would be violating our Massachusetts town’s mask order, but the photo is from Portsmouth, New Hampshire (“Stay Home or Die” will be the new license plate motto?) so they’re not breaking the law there.)

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Science-denying Covidiots in Pittsburgh reopen their business

Science-deniers defy and deny the settled science and, what’s worse, suggest that Covid-19 may not be a more serious problem than influenza:

Yealy was asked whether people should worry about COVID-19 more than the regular flu. He said people should be “worried differently,” pointing out that both take their heaviest toll on the elderly, especially nursing home residents, and people weakened by other medical conditions.

Yealy said he “would not think of it as more or less, just two different illnesses that share some features, but have some distinct differences.”

These people are reopening their business, prioritizing money over human life, justifying their lust for cash by claiming that “the death rate for people infected with the new coronavirus may be as low as 0.25%”.

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Rapunzel’s mom inspires our media and politicians?

Happy Mother’s Day to those readers who identify as “mothers”!

Conversation with a 10-year-old:

  • Why do they tell us to wear masks and avoid crowds if we can’t catch coronavirus?
  • When adults want children to do something for their benefit, one good strategy is to tell the children that it is actually for their own benefit.
  • Like Mother Gothel in Tangled!

For readers unfamiliar with this epic retelling of the Rapunzel story, the senior citizen Mother Gothel (a witch who identifies as Rapunzel’s mom) keeps the healthy 18-year-old imprisoned by telling her that the outside world is full of danger and peril.

Look at you, as fragile as a flower
Still a little sapling, just a sprout
You know why we stay up in this tower

That’s right, to keep you safe and sound, dear
Guess I always knew this day was coming
Knew that soon you’d want to leave the nest
Soon, but not yet

Listen to your mother
It’s a scary world out there
Mother knows best
One way or another
Something will go wrong, I swear
Ruffians, thugs
Poison ivy, quicksand
Cannibals and snakes
The plague

(Lyricist Glenn Slater should get a prize for that last line!)

Although the typical Covid-19-tagged death in Massachusetts is of an 82-year-old with “underlying conditions” (more than 98 percent), our media tends to feature healthy young people cut down in their prime by the evil virus, an ever-present lurker in any activity that young people might formerly have enjoyed. The result is a remarkably high number of healthy young people isolating themselves out of personal fear, just as Rapunzel isolated herself voluntarily until shortly before the movie picks up her story.

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Is it more difficult to be a mother today compared to 1,000, 10,000, or 100,000 years ago?

From our local public radio station: “I Love My Kids But I Loathe Mother’s Day — Especially This Year”.

… our culture has a pretty long rap sheet of under-appreciating women. And day in and day out, those moms tend to not get the credit they deserve because they make so much look easy: holding together infinite moving parts to accomplish the mission of the family machine, plus adding glitter. Metaphorical glitter. Sometimes real glitter, added by real children. Which the moms are usually stuck cleaning up.

The truth is, of course, that at this moment nothing’s okay for anybody. And I get that it isn’t the holiday’s fault that we need to adjust gender and work roles and laws and unwritten rules. But right now, it’s easier to imagine a marginally improved version of Mother’s Day (minus the false pedestal mess) than to dare to dream of civilizational change.

Solidarity, moms. Each and every one of you: Happy sub-optimal holiday in these sub-optimal times to some of the most superoptimal people on Earth.

In other words, something humans have been doing for 200,000 years is now intolerably burdensome, despite a climate-conditioned home packed with labor-saving machines.

Readers: Is motherhood in fact now more burdensome than in earlier eras? Or it was always intolerably burdensome, but mothers did not have as many outlets for complaining about the burden so we don’t how unhappy women were in Ancient Athens, Siddhattha Gotama’s India, or the China of Confucius?

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Swiss: children can’t transmit coronavirus, but teachers shouldn’t rush back to work

BBC story, April 29:

Swiss authorities say it is now safe for children under the age of 10 to hug their grandparents, in a revision to official advice on coronavirus.

The health ministry’s infectious diseases chief Daniel Koch said scientists had concluded that young children did not transmit the virus.

This week, garden centres and hairdressers have been allowed to open their doors. Schools and shops selling items other than food will be allowed to reopen in two weeks’ time.

Dr Koch told a news conference this week that the original advice to keep distance between children and their grandparents was made when less was known about how the coronavirus was transmitted.

“Young children are not infected and do not transmit the virus,” he said. “They just don’t have the receptors to catch the disease.”

So they have known for a while that there was no way that children could be involved in coronaplague transmission, but the teachers still needed at least two more weeks of vacation!

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